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Altering Gene Expression

From the desk of Dr Sam Shohet BDS MGDS RCS(Eng) LiAc MBAcC ICAK

It is all very well carrying out exhaustive and complex research to isolate individual genes thought to be responsible for various diseases but, when it comes to manipulating these genes in order to effect a better outcome, this has been fraught with problems and has proved to be virtually impossible without serious side-effects.

So where do we go from here?

The DNA Code

DNA is made up of a sequence of proteins in groups of four amino acids:

A Adenine

C Cytosine

G Guanine and

T Thymidine.

In RNA the T is replaced by a U Uracil.

The DNA Helix Simplified

An easy way to look at Genes which are sequences or strands of DNA groups of the above amino acids, is to imagine a typical household ladder with two uprights connected by rungs and then twisted - hey presto the DNA helix!

DNA Repair and Maintenance

DNA, like any other protein in the body, is under constant attack by oxygen molecules called free radicals. It is estimated that our DNA sustains almost 500 hits every day which could lead to damage of one or  more of the amino acid molecules. This damage, or break to the DNA, can be repaired by an enzyme in the body which is zinc dependant - hence the fundamental importance of zinc for life itself.   The interesting thing about the uprights of the DNA ladder or the sides of the helix is that they are mirror images of each other and are therefore easy to reproduce should one protein become damaged. 

SNiPs or Single Nucleotide Polymorphism

But what happens when the damage takes place on both sides at the same time and there is no way for the amino acid to be replaced accurately? In instances like these, the damaged amino acid is replaced by whatever protein is available at the time. So if the sequence has lost an A from both sides, the body might repair that with a C, a G, a T or even a U.
This change in the DNA code creates a completely different set of information for the gene and therefore changes its behaviour or expression. This change is what is called a SNiP or polymorphism.

Advantages and Disadvantages of SNiPs

Not all polymorphisms are bad. Some changes of gene expression make no difference at all to our everyday lives and some are even beneficial creating a change for the better. However, those changes that are not so good can code for problems that we might interpret as disease such as Alzheimer's, MS, multiple allergies and even cancer.

Inherited or Acquired

SNiPs are mostly the result of damage from pathogens such as viruses, bacteria, fungus and even parasites. Not all SNiPs are caused by damage to DNA which took place in our own lifetime, some are in fact inherited from our parents, gandparents or perhaps distant ancesters.

Treatment, Naturally

It does not matter whether a SNiP is inherited or acquired. What is important is to know that it is possible to repair the damage and return the DNA sequence to its original state without gene manipulation or medical intervention which always carry great risks and can only target the DNA of the Stem Cell.
This repair is done naturally by using the very methods the body uses, ie, by using amino acids, vitamins, minerals, essential fatty acids, probiotics and so on.

Where is this Revolutionary Treatment Available?

At www.docsam.com of course, the very home of Natural Health Treatment.

With warm regards,

 

Sam Shohet